Objective:To discuss the diagnosis and treatment process of skull base osteoradionecrosis and improve the recognization of this disease. Method:We reviewd skull base and nasopharyngeal osteoradionecrosis in 7 patients retrospectively, including 5 nasopharyngeal carcinoma, 1 squamous cell carcinoma of sphenoid sinus, 1 adenoid cystic carcinoma; 6 patientd received skull base debridement surgery and the other one attempted but failed because of her unstable condition. Result:Follow-up period ranged from 3 to 31 months （mean 11.5 month）. During the review time, 2 patients died, 1 patient still had osteoradionecrosis with partly alleviated clinical symptom. At the latest follow-up visit, she was diagnosed as tumor recurrence and was advised to take targeted therapy by multi-discipline team; the symptom was significant improved in the rest of the patients. Conclusion:Osteoradionecrosis of skull base is often associated with other post-radiotherapy related complications. Once diagnosed definitely, extensive skull base debridement surgery should be performed in early time, which can significantly relieve symptoms, improve living quality and reduce the incidence of lethal complications.
目的：探讨颅底放射性骨髓炎诊治过程，提高诊疗水平。 方法：回顾性分析7例鼻咽颅底放射性骨髓炎患者的临床资料，5例为鼻咽癌，1例为蝶窦鳞状细胞癌，1例为腺样囊性癌；6例行鼻咽颅底清创手术，1例放弃手术治疗。 结果：术后随访3~31个月（平均11.5个月），2例死亡；1例术后症状部分缓解，随诊时肿瘤复发，同时伴有鼻咽颅底放射性骨髓炎，多学科会诊后建议行靶向减瘤；其余患者手术治疗后症状明显缓解。 结论：颅底放射性骨髓炎常合并其他放疗后相关并发症，确诊后应早期行扩大性的颅底清创术，可明显缓解症状，提高生活质量，降低致死性并发症的发生率。.
Keywords: endoscopic surgical procedures; nasopharyngeal neoplasms; osteoradionecrosis of nasopharynx and skullbase.
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