Lipoprotein-based drug delivery

Abstract

Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and intestines. LPs play a major role in the transport of dietary and endogenous lipids to target cells through cell membrane receptors or cell surface-bound lipoprotein lipase. The stability, biocompatibility, and selective transport of LPs make them promising delivery vehicles for various therapeutic and imaging agents. This review discusses isolation, manufacturing, and drug loading techniques used for LP-based drug delivery, as well as recent applications for diagnosis and treatment of cancer, atherosclerosis, and other life-threatening diseases.

Keywords: Biocompatible nanoparticles; Chemotherapy; Chylomicrons; Drug delivery; High-density lipoproteins; Low-density lipoproteins; Lymphatic transport; Purification; Synthetic lipoproteins; Very low-density lipoproteins.