Acute resistance exercise-induced hypertensive stimulus impairs endothelial function in males. Because prior work indicates that female subjects have a tempered blood pressure response to acute resistance exercise, we hypothesized that, compared with males, females would better maintain endothelial function following resistance exercise and that this preservation would be associated with a lower hypertensive stimulus. Twenty-nine young healthy males (n = 16) and females (n = 13) participated in this study. All subjects performed a session of resistance exercise (leg extension) at the same relative workload [65% of one repetition maximum (1RM)]. The blood pressure response to exercise was characterized, and brachial artery flow-mediated dilation (FMD) was measured before and after. Males performed a second experimental trial in which the blood pressure response to resistance exercise was matched to that of females. This was accomplished by reducing the workload (~25% of 1RM). When resistance exercise was performed at the same relative workload, the systolic blood pressure was greater in males compared with females. Congruently, resistance exercise caused a significant impairment in FMD in males but not in females (P < 0.001). When the exercise workload was reduced in males, they no longer displayed an impairment in FMD following resistance exercise and, as such, the sex difference was abolished (P > 0.05). The present study reveals that acute resistance exercise transiently impairs endothelial function in young, healthy males but not in age-matched females. Notably, the maintenance of endothelial function in females is associated with a lower blood pressure response during resistance exercise.NEW & NOTEWORTHY The present data demonstrate for the first time that acute resistance exercise impairs endothelial function in young, healthy male but not female subjects. In addition, we show that the preservation of endothelial function in females is associated with a mitigated blood pressure response during resistance exercise. Accordingly, this work portrays a sexual dimorphism in the barostress response, and ensuing vascular effects, to resistance exercise.
Keywords: flow-mediated dilation; hypertension; resistance exercise; sex difference; vascular function.