SARS-CoV-2 on the ocular surface: is it truly a novel transmission route?

Br J Ophthalmol. 2021 Sep;105(9):1190-1195. doi: 10.1136/bjophthalmol-2020-316263. Epub 2020 Aug 11.

Abstract

Since December 2019, the novel COVID-19 outbreak has spread rapidly around the globe and infected millions of people. Although the major transmission route of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is considered to be airborne droplets and close contact, the ocular transmission route has been reported with great concern. The current work summarises the characteristics of SARS-CoV-2, the ocular distribution of the major SARS-CoV-2 binding protein, and the experimental and clinical evidence of the ocular transmission route. Although it seems that the likelihood of the ocular surface being an infection gateway is low, SARS-CoV-2 infection or transmission via the ocular surface may cause conjunctivitis and other ocular discomfort. Therefore, good eye protection is an essential safeguard procedure, especially for medical staff.

Keywords: Conjunctiva; Microbiology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • COVID-19 / epidemiology
  • COVID-19 / transmission*
  • Disease Transmission, Infectious / statistics & numerical data*
  • Eye Infections, Viral / epidemiology*
  • Eye Infections, Viral / virology
  • Humans
  • Pandemics
  • SARS-CoV-2*