Computational evaluation of dose distribution for BNCT treatment combined with X-ray therapy or proton beam therapy

Kenta Takada; Hiroaki Kumada; Akira Matsumura; Hideyuki Sakurai; Takeji Sakae

doi:10.1016/j.apradiso.2020.109295

Computational evaluation of dose distribution for BNCT treatment combined with X-ray therapy or proton beam therapy

Appl Radiat Isot. 2020 Nov:165:109295. doi: 10.1016/j.apradiso.2020.109295. Epub 2020 Jul 6.

Authors

Kenta Takada¹, Hiroaki Kumada², Akira Matsumura², Hideyuki Sakurai², Takeji Sakae²

Affiliations

¹ Department of Radiological Technology, Gunma Prefectural College of Health Sciences, 323-1 Kamiokimachi, Maebashi, Gunma, 371-0052, Japan; Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. Electronic address: k-takada@gchs.ac.jp.
² Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

PMID: 32784126
DOI: 10.1016/j.apradiso.2020.109295

Abstract

In this study, we performed Monte Carlo simulations to accurately reflect the beam delivery systems including patient-specific irradiation devices of X-ray and proton beam therapies. The dose distributions obtained from the simulations for X-rays or proton beams were successfully combined to the dose distribution of boron neutron capture therapy (BNCT), which was calculated by a treatment planning system called Tsukuba Plan. The results demonstrate the feasibility of dose evaluation for BNCT combined with other radiotherapy modalities using the Tsukuba Plan.

Keywords: BNCT; Combined radiotherapy; Dose evaluation system; PHITS simulation; Tsukuba Plan.

MeSH terms

Boron Neutron Capture Therapy / methods*
Feasibility Studies
Humans
Proton Therapy / methods*
Radiotherapy Dosage
Reproducibility of Results
X-Ray Therapy / methods*