Short-term PM2.5 exposure and circulating von Willebrand factor level: a meta-analysis

Qingqing Liang; Mengqi Sun; Fenghong Wang; Yuexiao Ma; Lisen Lin; Tianyu Li; Junchao Duan; Zhiwei Sun

doi:10.1016/j.scitotenv.2020.140180

Short-term PM_2.5 exposure and circulating von Willebrand factor level: a meta-analysis

Sci Total Environ. 2020 Oct 1:737:140180. doi: 10.1016/j.scitotenv.2020.140180. Epub 2020 Jun 15.

Authors

Qingqing Liang¹, Mengqi Sun², Fenghong Wang², Yuexiao Ma², Lisen Lin², Tianyu Li², Junchao Duan³, Zhiwei Sun⁴

Affiliations

¹ Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China; School of Public Health, Baotou Medical College, Inner Mongolia University of Science & Technology, Baotou 014040, PR China.
² Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China.
³ Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China. Electronic address: jcduan@ccmu.edu.cn.
⁴ Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China. Electronic address: zwsun@ccmu.edu.cn.

PMID: 32783836
DOI: 10.1016/j.scitotenv.2020.140180

Abstract

Background: Ambient fine particulate matter (PM_2.5) is a major threat to cardiovascular health. Endothelial dysfunction is the initiating event associated with the PM_2.5-induced cardiovascular disease (CVD). A sensitive marker of endothelial function-circulating von Willebrand factor (vWF), is an independent predictor of adverse clinical outcome in CVD patients. PM_2.5 exposure may cause CVD, but the reports of relationship between short-term PM_2.5 exposure and circulating vWF are inconsistent.

Objective: To explore the influence of short-term PM_2.5 exposure on circulating vWF.

Methods: By using a combination of computer and manual retrieval, a systematic literature retrieval was conducted on PubMed, Cochrane Library, Web of Science, Embase and Scopus databases up to October 2019. The heterogeneity among studies was tested by Stata 12.0, and the pooled %-change (percentage change per 10 μg/m³ increase in PM_2.5) and its 95% confidence interval (95%CI) were calculated by using random effect model. Sensitivity analysis and publication bias detection were also carried out.

Results: 12 articles were included in this meta-analysis. Short-term PM_2.5 exposure (per 10 μg/m³ increase) was associated with the increased vWF (%-change = 0.41, 95%CI: 0.11-0.71). The pooled effect estimates of subgroup with PM_2.5 exposure level < 25 μg/m³ was higher (%-change = 8.26; 95%CI: 1.99-14.53) than that with PM_2.5 exposure level ≥ 25 μg/m³ (%-change = 0.36; 95%CI: 0.09-0.63).

Conclusion: Short-term PM_2.5 exposure is associated with the increased circulating vWF. It suggests that short-term PM_2.5 exposure causes endothelial dysfunction.

Keywords: PM(2.5); cardiovascular disease; endothelial dysfunction; meta-analysis; von Willebrand factor.

Publication types

Meta-Analysis
Review

MeSH terms

Air Pollutants / analysis*
Air Pollution / analysis*
Biomarkers
Cardiovascular Diseases*
Databases, Factual
Environmental Exposure / analysis
Humans
Particulate Matter / analysis
von Willebrand Factor

Substances

Air Pollutants
Biomarkers
Particulate Matter
von Willebrand Factor