Attenuation of inflammatory response in the EAE model by PEGlated nanoliposome of pistachio oils

Ali Jebali; Mojgan Noroozi Karimabad; Zahra Ahmadi; Hossein Khorramdel; Ayat Kaeidi; Mohammadreza Mirzaei; Mohammad Zare-Bidaki; Hassan Ahmadinia; Alireza Vakilian; Ali Darekordi; Gholamhossein Hassanshahi

doi:10.1016/j.jneuroim.2020.577352

Attenuation of inflammatory response in the EAE model by PEGlated nanoliposome of pistachio oils

J Neuroimmunol. 2020 Oct 15:347:577352. doi: 10.1016/j.jneuroim.2020.577352. Epub 2020 Jul 30.

Affiliations

¹ Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
² Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
³ Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
⁴ Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
⁵ Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
⁶ Department of epidemiology and biostatics, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
⁷ Department of Internal Medicine, School of Medicine, Non-Communicable Diseases Research Center, Ali Ibn Abitaleb Educational and Treatment Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Neurology Department, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
⁸ Department of Chemistry, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran.
⁹ Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Electronic address: ghassanshahi@gmail.com.

PMID: 32781342
DOI: 10.1016/j.jneuroim.2020.577352

Abstract

The aim of this study was to investigate the effect of PEGlated nanoliposome of pistachio unsaturated oils (PEGNLPUOs) to attenuate the inflammatory response in the EAE model by modulating of NFKB and oxidative stress signaling pathway. Real-time PCR demonstrated that the administration of 10%v/v PEGNLPUOs significantly decreased the expression level of AKT1, MAPK, and NFKB genes from NFKB signaling pathway and MGST1, NOS2, and HO-1 genes from oxidative stress signaling pathway. This study showed that the administration of pistachio oil and PEGNLPUOs at a concentration of 10%v/v decreased the number and percentage of Th1(CD4+) and increased Th2(CD8+) cells.

Keywords: NFKB signaling pathway; Oxidative stress signaling pathway; PEGlated nanoliposome; Pistachio oils.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Encephalomyelitis, Autoimmune, Experimental / drug therapy*
Encephalomyelitis, Autoimmune, Experimental / metabolism
Inflammation Mediators / antagonists & inhibitors*
Inflammation Mediators / metabolism
Liposomes
Mice
Nanoparticles / administration & dosage*
Pistacia*
Plant Oils / isolation & purification
Plant Oils / pharmacology
Plant Oils / therapeutic use*
Polyethylene Glycols / administration & dosage*

Substances

Inflammation Mediators
Liposomes
Plant Oils
Polyethylene Glycols