GCSBA-Net: Gabor-Based and Cascade Squeeze Bi-Attention Network for Gland Segmentation

IEEE J Biomed Health Inform. 2021 Apr;25(4):1185-1196. doi: 10.1109/JBHI.2020.3015844. Epub 2021 Apr 7.

Abstract

Colorectal cancer is the second and the third most common cancer in women and men, respectively. Pathological diagnosis is the "gold standard" for tumor diagnosis. Accurate segmentation of glands from tissue images is a crucial step in assisting pathologists in their diagnosis. The typical methods for gland segmentation form a dense image representation, ignoring its texture and multi-scale attention information. Therefore, we utilize a Gabor-based module to extract texture information at different scales and directions in histopathology images. This paper also designs a Cascade Squeeze Bi-Attention (CSBA) module. Specifically, we add Atrous Cascade Spatial Pyramid (ACSP), Squeeze Position Attention (SPA) module and Squeeze Channel Attention module (SCA) to model semantic correlation and maintain the multi-level aggregation on the spatial pyramid with different dilations. Besides, to solve the imbalance of data distribution and boundary blur, we propose a hybrid loss function to response the object boudary better. The experimental results show that the proposed method achieves state-of-the-art performance on the GlaS challenge dataset and CRAG colorectal adenocarcinoma dataset, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colorectal Neoplasms* / diagnostic imaging
  • Female
  • Humans
  • Image Processing, Computer-Assisted*
  • Male
  • Neural Networks, Computer
  • Semantics