Should we screen patients with hematologic malignancies for COVID-19?

Hematol Oncol. 2020 Dec;38(5):648-653. doi: 10.1002/hon.2780. Epub 2020 Aug 8.

Abstract

The coronavirus disease (COVID-19) pandemic has posed several challenges to the hematology community to re-organize the medical care of patients with hematologic malignancies. Whereas the oncology societies favored a more or less conservative approach which considered the possibility of delaying treatment administration on a case-by-case basis, the hematology community guidelines were less stringent and recommended adequate individualized regimens. As countries are de-escalating the lockdown and the medical community is unable to foresee the end of the current outbreak will and whether the pandemic would eventually come back as a seasonal infection, there is interest in screening of patients with hematology malignancies with COVID-19 instead of limiting access to curative treatments. The rapidly accumulating knowledge about COVID-19 allows a better understanding of the diagnostic tools that may be potentially used in screening. Herein, we briefly review the pathophysiology of COVID-19, the rationale of screening of patients with hematologic malignancies, tools for screening, and available guidelines.

Keywords: COVID-19; leukemia; lymphoma; multiple myeloma; polymerase chain reaction; screening.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage
  • Adrenal Cortex Hormones / adverse effects
  • Adrenal Cortex Hormones / therapeutic use
  • Antineoplastic Agents, Immunological / administration & dosage
  • Antineoplastic Agents, Immunological / adverse effects
  • Antineoplastic Agents, Immunological / therapeutic use
  • COVID-19 / complications*
  • COVID-19 / diagnosis*
  • COVID-19 / etiology
  • COVID-19 / virology
  • Clinical Decision-Making
  • Colony-Stimulating Factors / administration & dosage
  • Colony-Stimulating Factors / adverse effects
  • Colony-Stimulating Factors / therapeutic use
  • Disease Management
  • Disease Susceptibility / immunology
  • Hematologic Neoplasms / complications*
  • Hematologic Neoplasms / therapy
  • Humans
  • Immunocompromised Host
  • Mass Screening
  • Molecular Diagnostic Techniques
  • Molecular Targeted Therapy / adverse effects
  • Molecular Targeted Therapy / methods
  • Practice Guidelines as Topic
  • SARS-CoV-2*

Substances

  • Adrenal Cortex Hormones
  • Antineoplastic Agents, Immunological
  • Colony-Stimulating Factors