Photothermal therapy technology of metastatic colorectal cancer

Junji Chen; Ziwei Zeng; Liang Huang; Shuangling Luo; Jianghui Dong; Fiona H Zhou; Kun Zhou; Liping Wang; Liang Kang

Photothermal therapy technology of metastatic colorectal cancer

Am J Transl Res. 2020 Jul 15;12(7):3089-3115. eCollection 2020.

Authors

Junji Chen^{1

2}, Ziwei Zeng^{1

2}, Liang Huang^{1

2}, Shuangling Luo^{1

2}, Jianghui Dong³, Fiona H Zhou⁴, Kun Zhou³, Liping Wang³, Liang Kang^{1

2}

Affiliations

¹ Department of Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-Sen University Guangzhou 510655, Guangdong, China.
² Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-Sen University Guangzhou 510655, Guangdong, China.
³ UniSA Clinical and Health Sciences, and UniSA Cancer Research Institute, University of South Australia Adelaide, SA 5001, Australia.
⁴ School of Medicine, University of Adelaide Adelaide, SA 5000, Australia.

PMID: 32774688
PMCID: PMC7407689

Abstract

Colorectal cancer (CRC) is one of the most common malignancies. The current treatments of metastatic colorectal cancer (mCRC) are ineffective and the bottleneck problem. It is of significance to explore effective new therapeutic strategies to eradicate mCRC. Photothermal therapy (PTT) is an emerging technology for tumor therapy, with the potential in the treatment of mCRC. In this review, the current treatment approaches to mCRC including surgery, radiotherapy, chemotherapy interventional therapy, biotherapy, and photothermal therapy are reviewed. In addition, we will focus on the various kinds of nanomaterials used in PTT for the treatment of CRC both in vitro and in vivo models. In conclusion, we will summarize the combined application of PTT with other theranostic methods, and propose future research directions of PTT in the treatment of CRC.

Keywords: Mucinous adenocarcinoma; colorectal cancer; colorectal carcinoma; photothermal therapy.

Publication types

Review