Cynanchum paniculatum and Its Major Active Constituents for Inflammatory-Related Diseases: A Review of Traditional Use, Multiple Pathway Modulations, and Clinical Applications

Jing-Xian Chen; Chien-Shan Cheng; Jie Chen; Ling-Ling Lv; Zi-Jie Chen; Chuan Chen; Lan Zheng

doi:10.1155/2020/7259686

Cynanchum paniculatum and Its Major Active Constituents for Inflammatory-Related Diseases: A Review of Traditional Use, Multiple Pathway Modulations, and Clinical Applications

Evid Based Complement Alternat Med. 2020 Jul 22:2020:7259686. doi: 10.1155/2020/7259686. eCollection 2020.

Authors

Jing-Xian Chen^{1

2}, Chien-Shan Cheng^{3

4}, Jie Chen⁵, Ling-Ling Lv¹, Zi-Jie Chen⁶, Chuan Chen⁷, Lan Zheng^{1

2}

Affiliations

¹ Department of Traditional Chinese Medicine, Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital, Shanghai 200025, China.
² Workstation of Xia Xiang, National Master of Traditional Chinese Medicine, Department of Traditional Chinese Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
³ Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
⁴ Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
⁵ Department of Orthopedics, Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
⁶ Shanghai Yangpu Hospital of Traditional Chinese Medicine, Shanghai 200090, China.
⁷ Shanghai Geriatrics Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, China.

Abstract

Cynanchum paniculatum Radix, known as Xuchangqing in Chinese, is commonly prescribed in Chinese Medicine (CM) for the treatment of various inflammatory diseases. The anti-inflammatory property of Cynanchum paniculatum can be traced from its wind-damp removing, collaterals' obstruction relieving, and toxins counteracting effects as folk medicine in CM. This paper systematically reviewed the research advancement of the pharmacological effects of Cynanchum paniculatum among a variety of human diseases, including diseases of the respiratory, circulatory, digestive, urogenital, hematopoietic, endocrine and metabolomic, neurological, skeletal, and rheumatological systems and malignant diseases. This review aims to link the long history of clinical applications of Cynanchum paniculatum in CM with recent biomedical investigations. The major bioactive chemical compositions of Cynanchum paniculatum and their associated action mechanism unveiled by biomedical investigations as well as the present clinical applications and future perspectives are discussed. The major focuses of this review are on the diverse mechanisms of Cynanchum paniculatum and the role of its active components in inflammatory diseases.

Publication types

Review