WNT-activated embryonal tumors of the pineal region: ectopic medulloblastomas or a novel pineoblastoma subgroup?

Anthony P Y Liu; Loudy P Priesterbach-Ackley; Brent A Orr; Bryan K Li; Brian Gudenas; Roel E Reddingius; Mariona Suñol; Cinzia E Lavarino; Nagore G Olaciregui; Vicente Santa-María López; Michael J Fisher; Lili-Naz Hazrati; Eric Bouffet; Annie Huang; Giles W Robinson; Pieter Wesseling; Paul A Northcott; Amar Gajjar

doi:10.1007/s00401-020-02208-9

WNT-activated embryonal tumors of the pineal region: ectopic medulloblastomas or a novel pineoblastoma subgroup?

Acta Neuropathol. 2020 Oct;140(4):595-597. doi: 10.1007/s00401-020-02208-9. Epub 2020 Aug 8.

Authors

Anthony P Y Liu¹, Loudy P Priesterbach-Ackley², Brent A Orr³, Bryan K Li^{4

5

6}, Brian Gudenas⁷, Roel E Reddingius⁸, Mariona Suñol⁹, Cinzia E Lavarino¹⁰, Nagore G Olaciregui¹⁰, Vicente Santa-María López¹¹, Michael J Fisher¹², Lili-Naz Hazrati¹³, Eric Bouffet⁴, Annie Huang^{4

5

6

14}, Giles W Robinson¹⁵, Pieter Wesseling^{2

8}, Paul A Northcott⁷, Amar Gajjar¹⁵

Affiliations

¹ Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-3678, USA. anthony.liu@stjude.org.
² Department of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, The Netherlands.
³ Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
⁴ Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
⁵ Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada.
⁶ Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
⁷ Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
⁸ Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
⁹ Department of Pathology, Hospital Sant Joan de Déu, Barcelona, Spain.
¹⁰ Laboratory of Molecular Oncology, Hospital Sant Joan de Déu, Fundación Sant Joan de Déu, Barcelona, Spain.
¹¹ Department of Neuro-Oncology, Hospital Sant Joan de Déu, Barcelona, Spain.
¹² Division of Oncology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
¹³ Division of Pathology, The Hospital for Sick Children, Toronto, ON, Canada.
¹⁴ Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
¹⁵ Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-3678, USA.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Brain Neoplasms / genetics
Brain Neoplasms / metabolism
Brain Neoplasms / pathology*
Cerebellar Neoplasms / genetics
Cerebellar Neoplasms / metabolism
Cerebellar Neoplasms / pathology
Female
Humans
Male
Medulloblastoma / genetics
Medulloblastoma / metabolism
Medulloblastoma / pathology
Mutation, Missense / genetics
Neoplasms, Germ Cell and Embryonal / genetics
Neoplasms, Germ Cell and Embryonal / metabolism
Neoplasms, Germ Cell and Embryonal / pathology*
Pineal Gland / pathology*
Pinealoma / genetics
Pinealoma / metabolism
Pinealoma / pathology*
Wnt Proteins / metabolism
beta Catenin / genetics

Substances

CTNNB1 protein, human
Wnt Proteins
beta Catenin

Grants and funding

P30 CA021765/CA/NCI NIH HHS/United States