MRGPRX2 Activation Causes Increased Skin Reactivity in Patients with Chronic Spontaneous Urticaria

J Invest Dermatol. 2021 Mar;141(3):678-681.e2. doi: 10.1016/j.jid.2020.06.030. Epub 2020 Aug 7.

Authors

Maria Shtessel¹, Nathachit Limjunyawong², Eric T Oliver³, Kristin Chichester³, Li Gao³, Xinzhong Dong⁴, Sarbjit S Saini³

Affiliations

¹ Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA. Electronic address: ms5664@cumc.columbia.edu.
² The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
³ Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁴ The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

PMID: 32771471
DOI: 10.1016/j.jid.2020.06.030

No abstract available

Publication types

Letter
Observational Study
Research Support, N.I.H., Extramural

MeSH terms

Adolescent
Adult
Aged
Atracurium / administration & dosage*
Bradykinin / administration & dosage
Bradykinin / analogs & derivatives*
Case-Control Studies
Cell Line
Chronic Urticaria / diagnosis*
Chronic Urticaria / immunology
Female
Gene Knockout Techniques
Healthy Volunteers
Humans
Injections, Subcutaneous
Male
Middle Aged
Nerve Tissue Proteins / agonists
Nerve Tissue Proteins / genetics
Nerve Tissue Proteins / metabolism*
Receptors, G-Protein-Coupled / agonists
Receptors, G-Protein-Coupled / genetics
Receptors, G-Protein-Coupled / metabolism*
Receptors, Neuropeptide / agonists
Receptors, Neuropeptide / genetics
Receptors, Neuropeptide / metabolism*
Skin / drug effects
Skin / immunology
Skin Tests / methods
Young Adult

Substances

MRGPRX2 protein, human
Nerve Tissue Proteins
Receptors, G-Protein-Coupled
Receptors, Neuropeptide
Atracurium
icatibant
Bradykinin

Grants and funding