Diagnosis and Monitoring of Osteoporosis with Total-Body 18F-Sodium Fluoride-PET/CT

Vincent Zhang; Benjamin Koa; Austin J Borja; Sayuri Padmanhabhan; Abhijit Bhattaru; William Y Raynor; Chaitanya Rojulpote; Siavash Mehdizadeh Seraj; Thomas J Werner; Chamith Rajapakse; Abass Alavi; Mona-Elisabeth Revheim

doi:10.1016/j.cpet.2020.06.011

Diagnosis and Monitoring of Osteoporosis with Total-Body ¹⁸F-Sodium Fluoride-PET/CT

PET Clin. 2020 Oct;15(4):487-496. doi: 10.1016/j.cpet.2020.06.011. Epub 2020 Aug 4.

Affiliations

¹ Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
² Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; Drexel University College of Medicine, Philadelphia, PA, USA.
³ Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
⁴ Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; Department of Internal Medicine, The Wright Center for Graduate Medical Education, Scranton, PA, USA.
⁵ Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. Electronic address: abass.alavi@pennmedicine.upenn.edu.
⁶ Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

PMID: 32768370
DOI: 10.1016/j.cpet.2020.06.011

Abstract

In recent years, ¹⁸F-Sodium Fluoride (NaF)-PET/CT has seen its role in the detection and management of osteoporosis increase. This article reviews the extent of this application in the literature, its efficacy compared with other comparable imaging tools, and how total-body PET/CT combined with global disease assessment can revolutionize measurement of total osteoporotic disease activity. NaF-PET/CT eventually can be the modality of choice for metabolic bone disorders, especially with these advances in technology and computation.

Keywords: Global Disease Assessment; NaF; Osteoporosis; PET/CT; Total-body PET/CT.

Publication types

Review

MeSH terms

Bone and Bones / diagnostic imaging
Fluorine Radioisotopes*
Humans
Osteoporosis / diagnostic imaging*
Positron Emission Tomography Computed Tomography / methods*
Sodium Fluoride*
Whole Body Imaging / methods*

Substances

Fluorine Radioisotopes
Sodium Fluoride
Fluorine-18