Advances in Preclinical PET Instrumentation

Mahsa Amirrashedi; Habib Zaidi; Mohammad Reza Ay

doi:10.1016/j.cpet.2020.06.003

Advances in Preclinical PET Instrumentation

PET Clin. 2020 Oct;15(4):403-426. doi: 10.1016/j.cpet.2020.06.003. Epub 2020 Aug 4.

Authors

Mahsa Amirrashedi¹, Habib Zaidi², Mohammad Reza Ay³

Affiliations

¹ Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran.
² Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva CH-1211, Switzerland; Geneva University Neurocenter, Geneva University, Geneva CH-1205, Switzerland; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, Netherlands; Department of Nuclear Medicine, University of Southern Denmark, Odense 500, Denmark.
³ Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: mohammadreza_ay@sina.tums.ac.ir.

PMID: 32768368
DOI: 10.1016/j.cpet.2020.06.003

Abstract

In the light of ever-increasing demands for PET scanner with better resolvability, higher sensitivity and wide accessibility for noninvasive screening of small structures and physiological processes in laboratory rodents, several dedicated PET scanners were developed and evaluated. Understanding conceptual design constraints pros and cons of different configurations and impact of the major components will be helpful to further establish the crucial role of these miniaturized systems in a broad spectrum of modern research. Hence, a comprehensive review of preclinical PET scanners developed till early 2020 with particular emphasis on innovations in instrumentation and geometrical designs is provided.

Keywords: Design; Instrumentation; Performance; Preclinical PET scanner; Small-animal PET imaging.

Publication types

Review

MeSH terms

Animals
Humans
Models, Animal
Positron-Emission Tomography / methods*