Research Development, Optimization and Modifications of Anti-cancer Peptides

Mini Rev Med Chem. 2021;21(1):58-68. doi: 10.2174/1389557520666200729163146.

Abstract

Anti-cancer peptides play an important role in the area of cancer inhibition. A variety of anti- cancer peptides have emerged through the extraction and structural modification of peptides from biological tissues. This review provides the research background of anti-cancer peptides, the introduction of the mechanism of anti-cancer peptides for inhibition of cancers, the discovery and development along with optimization and modifications of these peptides in the clinical application. In conclusion, it can be said that anti-cancer peptides will play a major role in the future oncologic clinic.

Keywords: Anti-cancer peptides; development; mechanisms; modifications; optimization; progress.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Proliferation / drug effects
  • Drug Design
  • Drug Development*
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Peptides / chemical synthesis
  • Peptides / chemistry
  • Peptides / pharmacology*

Substances

  • Antineoplastic Agents
  • Peptides