Characterization of the novel HLA-DQB1*05:235N allele by next-generation sequencing

HLA. 2021 Mar;97(3):254-255. doi: 10.1111/tan.14008. Epub 2021 Jan 5.

Abstract

DQB1*05:235N differs from DQB1*05:03:01:01 by one nucleotide substitution at position 123 in exon 2, resulting in a premature stop codon.

Keywords: HLA; HLA-DQB1*05:235N; new allele; next-generation sequencing.

MeSH terms

  • Alleles
  • Exons / genetics
  • HLA-DQ beta-Chains / genetics
  • High-Throughput Nucleotide Sequencing*
  • Humans

Substances

  • HLA-DQ beta-Chains
  • HLA-DQB1 antigen