Laser-induced breakdown spectroscopy (LIBS) is a technique capable of portable, quantitative elemental analysis; however, quantitative isotopic determination of samples in situ has not yet been demonstrated. This research demonstrates the ability of LIBS to quantitatively determine concentrations of 6Li in solid samples of lithium hydroxide monohydrate in a nominally 40 mTorr argon environment using chemometrics. Three chemometric analysis techniques (principal component regression, partial least squares regression, and neural networks analysis) are applied to spectra collected using a spectrometer with modest resolving power (λ/Δλ ≈ 27 000). This analysis suggests that bulk lithium isotopic assay can be determined using LIBS to within a 95% confidence interval in minutes to an hour for enrichment levels ranging from 3% to 85%. This has direct applications for the nuclear safeguards and geological exploration communities and others that desire a portable, stable isotope analytical technique. Additionally, isotope-specific self-absorption of atomic emission in a laser-produced plasma is observed for the first time.
Keywords: Laser-induced breakdown spectroscopy; artificial neural networks; chemometrics; field instrumentation; in-situ analysis; isotopic determination; lithium; partial least squares; principal component analysis; regression.