Clinical and Epidemiological Features of 46 Children <1 Year Old With Coronavirus Disease 2019 in Wuhan, China: A Descriptive Study

J Infect Dis. 2020 Sep 14;222(8):1293-1297. doi: 10.1093/infdis/jiaa472.

Abstract

The number of coronavirus disease 2019 (COVID-19) cases has exceeded 10 million. However, little is known about the epidemiology and clinical characteristics of COVID-19 infants. We collected medical information of 46 confirmed patients (<1 year old) and retrospectively analyzed epidemiological history, clinical symptoms, and laboratory test results. The median age was 5 (interquartile range, 2-7) months. Sixteen cases had fever and 27 cases had cough. Moderate disease was present in 40 cases and cardiac injury occurred in 38 cases, following by liver dysfunction in 20 cases and lymphocytosis in no cases. Of all infant patients, 2 received invasive mechanical ventilation and 1 died with multiple organ dysfunction syndrome.

Keywords: SARS-CoV-2; children; clinical features; outcome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Betacoronavirus / isolation & purification
  • COVID-19
  • China / epidemiology
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / epidemiology*
  • Coronavirus Infections / therapy
  • Cough / therapy
  • Cough / virology
  • Female
  • Fever / therapy
  • Fever / virology
  • Humans
  • Infant
  • Male
  • Multiple Organ Failure / therapy
  • Multiple Organ Failure / virology
  • Pandemics
  • Pneumonia, Viral / diagnosis
  • Pneumonia, Viral / epidemiology*
  • Pneumonia, Viral / therapy
  • Retrospective Studies
  • SARS-CoV-2
  • Treatment Outcome