Gold nanoparticles against respiratory diseases: oncogenic and viral pathogens review

Ther Deliv. 2020 Aug;11(8):521-534. doi: 10.4155/tde-2020-0071. Epub 2020 Aug 5.

Abstract

Nanoscale size-dependent properties give nanomaterials unique specifications that are robust in many applications of human medicine. Gold nanoparticles (AuNPs) have recently gained attention because of their unique optical, physical and electrical properties. AuNPs increase the efficacy of biomedical applications in diagnostic treatments for infectious diseases, by targeting or labeling target cells/bioactive compounds. However, it is imperative to develop the regimens for more accurate diagnostic tools, preventive care and effective therapy. Our critical and comprehensive review presents emerging avenues of molecular diagnostics as well as therapeutics translated into clinical approaches. This manuscript critically reviews the rampant future of AuNPs in the diagnosis and treatment of the most important diseases, such as cancer and viruses of respiratory system.

Keywords: COVID-19; cancer; coronavirus; gold nanoparticles; imaging; plasmonic; therapeutics.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / therapeutic use
  • Betacoronavirus / isolation & purification
  • COVID-19
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / therapy
  • Coronavirus Infections / virology
  • Drug Carriers / chemistry
  • Gold / chemistry*
  • Humans
  • Lung Diseases / diagnosis
  • Lung Diseases / therapy
  • Metal Nanoparticles / chemistry*
  • Neoplasms / diagnosis
  • Neoplasms / drug therapy
  • Pandemics
  • Phototherapy
  • Pneumonia, Viral / diagnosis
  • Pneumonia, Viral / therapy
  • Pneumonia, Viral / virology
  • SARS-CoV-2

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Gold