Anti-cytomegalovirus Immunoglobulin G Is Linked to CD4 T-cell Count Decay in Human Immunodeficiency Virus (HIV) Elite Controllers

Clin Infect Dis. 2021 Jul 1;73(1):144-147. doi: 10.1093/cid/ciaa1129.

Abstract

Elite controllers (ECs) are people living with human immunodeficiency virus (HIV) who spontaneously control viral replication without antiretroviral therapy. We observed that elevated anti-cytomegalovirus (CMV) immunoglobulin G (IgG) levels correlated with annual CD4 T-cell count decay in ECs independently of age, sex, and human leukocyte antigen (HLA) type. Elevated anti-CMV titers may favor disease progression in ECs.

Keywords: CD4 decay; HIV; cytomegalovirus; elite controllers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes
  • Cell Count
  • Cytomegalovirus
  • HIV Infections* / drug therapy
  • HIV-1*
  • Humans
  • Immunoglobulin G
  • Viral Load

Substances

  • Immunoglobulin G