Untangling iNKT Cell Function in Adipose Tissue Homeostasis

Ruth A Franklin; Ruslan Medzhitov

doi:10.1016/j.cmet.2020.07.003

Untangling iNKT Cell Function in Adipose Tissue Homeostasis

Cell Metab. 2020 Aug 4;32(2):148-149. doi: 10.1016/j.cmet.2020.07.003.

Authors

Ruth A Franklin¹, Ruslan Medzhitov²

Affiliations

¹ Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
² Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: ruslan.medzhitov@yale.edu.

PMID: 32755605
DOI: 10.1016/j.cmet.2020.07.003

Abstract

iNKT cells are important regulatory cells in metabolic health and disease. In this issue of Cell Metabolism, LaMarche et al. (2020) clarify the origin and heterogeneity of these unconventional T cells and identify the specific signals in adipose tissues that direct their function.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adipose Tissue
Homeostasis
Interleukin-10
Natural Killer T-Cells*

Substances

Interleukin-10

Grants and funding

HHMI/Howard Hughes Medical Institute/United States