Structure of the Pandemic

Structure. 2020 Aug 4;28(8):874-878. doi: 10.1016/j.str.2020.07.007.

Abstract

During global pandemics, the spread of information needs to be faster than the spread of the virus in order to ensure the health and safety of human populations worldwide. In our current crisis, the demand for SARS-CoV-2 drugs and vaccines highlights the importance of biological targets and their three-dimensional shape. In particular, structural biology as a field was poised to quickly respond to crises due to previous experience and expertise and because of its early adoption of open access practices.

MeSH terms

  • Betacoronavirus / chemistry*
  • COVID-19
  • Coronavirus 3C Proteases
  • Coronavirus Infections / epidemiology*
  • Coronavirus Infections / virology*
  • Coronavirus RNA-Dependent RNA Polymerase
  • Cysteine Endopeptidases / chemistry
  • Databases, Protein
  • Humans
  • Models, Molecular
  • Molecular Biology
  • Pandemics*
  • Pneumonia, Viral / epidemiology*
  • Pneumonia, Viral / virology*
  • Protein Conformation
  • RNA-Dependent RNA Polymerase / chemistry
  • SARS-CoV-2
  • Spike Glycoprotein, Coronavirus / chemistry
  • Viral Nonstructural Proteins / chemistry
  • Viral Proteins / chemistry*

Substances

  • Spike Glycoprotein, Coronavirus
  • Viral Nonstructural Proteins
  • Viral Proteins
  • spike protein, SARS-CoV-2
  • Coronavirus RNA-Dependent RNA Polymerase
  • NSP12 protein, SARS-CoV-2
  • RNA-Dependent RNA Polymerase
  • Cysteine Endopeptidases
  • Coronavirus 3C Proteases