Cryo-EM Uncovers Atomic Details for Loading Cell-Killing Enzymes to the Anthrax Toxin Pretranslocation Complex

Xiaodan Ni; Jiansen Jiang

doi:10.1016/j.str.2020.07.008

Cryo-EM Uncovers Atomic Details for Loading Cell-Killing Enzymes to the Anthrax Toxin Pretranslocation Complex

Structure. 2020 Aug 4;28(8):871-873. doi: 10.1016/j.str.2020.07.008.

Authors

Xiaodan Ni¹, Jiansen Jiang²

Affiliations

¹ Laboratory of Membrane Proteins and Structural Biology, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
² Laboratory of Membrane Proteins and Structural Biology, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: jiansen.jiang@nih.gov.

PMID: 32755568
DOI: 10.1016/j.str.2020.07.008

Abstract

In this issue of Structure, Zhou et al. report the structures of full-length lethal and edema factors, the cytotoxic components of the deadly anthrax toxin, in complex with the toxin's cell binding and delivery module, the protective antigen prechannel, providing an atomic description for the toxin recruitment prior to translocation.

Published by Elsevier Ltd.

Publication types

Research Support, N.I.H., Intramural
Comment

MeSH terms

Anthrax*
Antigens, Bacterial
Bacterial Toxins*
Cryoelectron Microscopy
Edema
Humans

Substances

Antigens, Bacterial
Bacterial Toxins
anthrax toxin