A rare case of a non-neural granular cell tumor presenting as an enlarging right chest wall nodule in a 4-year-old male and review of the literature

Ali Shahabi; Hope Hastings; Harry Winfield; Amer Khiyami

doi:10.1177/2050313X20938246

A rare case of a non-neural granular cell tumor presenting as an enlarging right chest wall nodule in a 4-year-old male and review of the literature

SAGE Open Med Case Rep. 2020 Jul 22:8:2050313X20938246. doi: 10.1177/2050313X20938246. eCollection 2020.

Authors

Ali Shahabi¹, Hope Hastings¹, Harry Winfield², Amer Khiyami¹

Affiliations

¹ Department of Pathology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.
² Department of Dermatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.

Abstract

Non-neural granular cell tumor was first described in 1991 as an unusual primitive, polypoid variant of the conventional granular cell tumor. To date, this neoplasm remains a rare entity and the cell of origin is uncertain. While the histological features are similar to the conventional granular cell tumor, it represents a distinct entity that is negative for S100 and lacks true nerve sheath differentiation. Here, we describe a case of a 4-year-old male who presented with a painless, soft nodule on his right chest wall that was slowly increasing in size. The mass was excised and sent for pathologic analysis. Microscopic examination reveals spindle and epithelioid cells with vesicular nuclei and prominent granular eosinophilic cytoplasm. Immunohistochemical analysis shows negative staining for S100 and AE1/AE3/PCK26 but is positive for CD68. A diagnosis of a non-neural granular cell tumor was made. We report a rare and diagnostically challenging case in a pediatric patient.

Keywords: S100; Skin; non-neural granular cell tumor.

Publication types

Case Reports