Emerging role of exosomes in craniofacial and dental applications

Theranostics. 2020 Jul 9;10(19):8648-8664. doi: 10.7150/thno.48291. eCollection 2020.

Abstract

Exosomes, a specific subgroup of extracellular vesicles that are secreted by cells, have been recognized as important mediators of intercellular communication. They participate in a diverse range of physiological and pathological processes. Given the capability of exosomes to carry molecular cargos and transfer bioactive components, exosome-based disease diagnosis and therapeutics have been extensively studied over the past few decades. Herein, we highlight the emerging applications of exosomes as biomarkers and therapeutic agents in the craniofacial and dental field. Moreover, we discuss the current challenges and future perspectives of exosomes in clinical applications.

Keywords: biomarker; craniofacial; dental; exosome; therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / metabolism
  • Cell Communication
  • Craniofacial Abnormalities / diagnosis*
  • Craniofacial Abnormalities / genetics
  • Craniofacial Abnormalities / metabolism
  • Early Diagnosis
  • Exosomes / genetics*
  • Exosomes / metabolism*
  • Humans
  • Precision Medicine
  • Stomatognathic Diseases / diagnosis*
  • Stomatognathic Diseases / genetics
  • Stomatognathic Diseases / metabolism

Substances

  • Biomarkers