Dying 'due to' or 'with' COVID-19: a cause of death analysis in hospitalised patients

Clin Med (Lond). 2020 Sep;20(5):e189-e190. doi: 10.7861/clinmed.2020-0440. Epub 2020 Aug 3.

Abstract

The SARS-CoV-2 pandemic is accompanied by an ever-rising death toll attributed to coronavirus disease 2019 (COVID-19), but questions have persisted regarding deaths formally attributed to COVID-19. We aimed to provide an independent review of clinical features of patients who died during hospitalisation with a positive PCR test for SARS-CoV-2 and relate these to the reported cause of death. Between 23 March and 28 April 2020, a total of 162 patients with a positive SARS-CoV-2 PCR died in our NHS trust. COVID-19 infection was documented as the direct cause of death in 150 (93%). Review of the records revealed 138 (92%) patients had pulmonary infiltrates on chest radiography, and 146 (97%) required oxygen therapy. This retrospective review of cause of death has demonstrated that the overwhelming majority of hospitalised patients with positive SARS-CoV-2 PCR died as a direct consequence of COVID-19 infection.

Keywords: COVID-19; SARS-CoV-2; coronavirus.

MeSH terms

  • COVID-19
  • Cause of Death*
  • Cohort Studies
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / mortality*
  • Coronavirus Infections / therapy
  • Female
  • Hospital Mortality / trends*
  • Hospitalization / statistics & numerical data*
  • Humans
  • Male
  • Pandemics
  • Pneumonia, Viral / diagnosis
  • Pneumonia, Viral / mortality*
  • Pneumonia, Viral / therapy
  • Retrospective Studies
  • United Kingdom