Dosing-related saturation of toxicity and accelerated drug clearance with pegaspargase treatment

Blood. 2020 Dec 17;136(25):2955-2958. doi: 10.1182/blood.2020006214.
No abstract available

Publication types

  • Letter
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asparaginase* / administration & dosage
  • Asparaginase* / adverse effects
  • Asparaginase* / pharmacokinetics
  • Drug Elimination Routes
  • Female
  • Humans
  • Male
  • Metabolic Clearance Rate
  • Polyethylene Glycols* / administration & dosage
  • Polyethylene Glycols* / adverse effects
  • Polyethylene Glycols* / pharmacokinetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / blood
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / drug therapy

Substances

  • Polyethylene Glycols
  • pegaspargase
  • Asparaginase