Ultraflexible Neural Electrodes for Long-Lasting Intracortical Recording

Fei He; Roy Lycke; Mehran Ganji; Chong Xie; Lan Luan

doi:10.1016/j.isci.2020.101387

Ultraflexible Neural Electrodes for Long-Lasting Intracortical Recording

iScience. 2020 Aug 21;23(8):101387. doi: 10.1016/j.isci.2020.101387. Epub 2020 Jul 20.

Authors

Fei He¹, Roy Lycke², Mehran Ganji², Chong Xie³, Lan Luan⁴

Affiliations

¹ Department of Electrical and Computer Engineering, Rice University, 6100 Main Street, Houston, TX 77005, USA; NeuroEngineering Initiative, Rice University, 6500 Main Street, Houston, TX 77005, USA.
² Department of Electrical and Computer Engineering, Rice University, 6100 Main Street, Houston, TX 77005, USA; NeuroEngineering Initiative, Rice University, 6500 Main Street, Houston, TX 77005, USA; Department of Biomedical Engineering, University of Texas at Austin, 107 Dean Keeton, Austin, TX 78712, USA.
³ Department of Electrical and Computer Engineering, Rice University, 6100 Main Street, Houston, TX 77005, USA; NeuroEngineering Initiative, Rice University, 6500 Main Street, Houston, TX 77005, USA; Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77005, USA.
⁴ Department of Electrical and Computer Engineering, Rice University, 6100 Main Street, Houston, TX 77005, USA; NeuroEngineering Initiative, Rice University, 6500 Main Street, Houston, TX 77005, USA; Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77005, USA. Electronic address: lan.luan@rice.edu.

Abstract

Implanted electrodes provide one of the most important neurotechniques for fundamental and translational neurosciences by permitting time-resolved electrical detection of individual neurons in vivo. However, conventional rigid electrodes typically cannot provide stable, long-lasting recordings. Numerous interwoven biotic and abiotic factors at the tissue-electrode interface lead to short- and long-term instability of the recording performance. Making neural electrodes flexible provides a promising approach to mitigate these challenges on the implants and at the tissue-electrode interface. Here we review the recent progress of ultraflexible neural electrodes and discuss the engineering principles, the material properties, and the implantation strategies to achieve stable tissue-electrode interface and reliable unit recordings in living brains.

Keywords: Bioelectrical Engingeering; Bioelectronics; Techniques in Neuroscience.

Publication types

Review

Abstract

Publication types

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