Childhood survivors of high-risk neuroblastoma show signs of immune recovery and not immunosenescence

Abstract

Neuroblastoma survivors show signs of immunosenescence early after therapy in CD8⁺ T cell compartment and elevated plasma TNF-α but in later follow-up immune recovery comes into play. Whether the recovery phenotype is long lasting or transient remains to be elucidated, however, late adverse effects often occur in childhood cancer survivors.

Keywords: adverse late effects; childhood; immune recovery; immunosenescence; neuroblastoma.