Abstract
Type 2 diabetes mellitus is a type of metabolic disorder characterized by hyperglycaemia with multiple serious complications, such as diabetic neuropathies, diabetic nephropathy, diabetic retinopathy, and diabetic foot. Platelet-derived growth factors are growth factors that regulate cell growth and division, playing a critical role in diabetes and its harmful complications. This review focused on the cellular mechanism of platelet-derived growth factors and their receptors on diabetes development. Furthermore, we raise some proper therapeutic molecular targets for the treatment of diabetes and its complications.
Keywords:
Diabetes mellitus; diabetic foot; diabetic nephropathy; diabetic neuropathies; diabetic retinopathy; platelet-derived growth factor; platelet-derived growth factor-targeted therapy.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Diabetes Complications / diagnosis
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Diabetes Complications / drug therapy
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Diabetes Complications / etiology
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Diabetes Complications / metabolism*
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Diabetes Mellitus, Type 2 / complications
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Diabetes Mellitus, Type 2 / diagnosis
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Diabetes Mellitus, Type 2 / drug therapy
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Diabetes Mellitus, Type 2 / metabolism*
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Humans
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Hypoglycemic Agents / therapeutic use
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Platelet-Derived Growth Factor / antagonists & inhibitors
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Platelet-Derived Growth Factor / metabolism*
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Platelet-Derived Growth Factor / therapeutic use
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Receptors, Platelet-Derived Growth Factor / antagonists & inhibitors
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Receptors, Platelet-Derived Growth Factor / metabolism*
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Signal Transduction
Substances
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Hypoglycemic Agents
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Platelet-Derived Growth Factor
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Receptors, Platelet-Derived Growth Factor