Objective: To investigate the effect of Bushen Jianpi formula (BSJP) therapy on survival of the patients with moderate and advanced hepatocellular carcinoma (HCC).
Methods: This was a five-year retrospective study, enrolling 209 adult patients with moderate and advanced HCC patients. Log-rank test, Cox regression analysis and Kaplan-Meier analysis was applied to analyze the data.
Results: The outcome of single-factor Kaplan-Meier analysis and Log-rank test showed that stage of Barcelona-clinic liver cancer (BCLC), locoregional therapy and BSJP therapy were three factors that dominantly influenced the survival of moderate and advanced HCC patients (P < 0.05). In Cox multiple-factor regression analysis, lower BCLC staging (RR = 2.016; P = 0.000), locoregional therapy (RR = 0.611; P = 0.011) and BSJP therapy (RR = 0.684; P = 0.044) were the independent protective factors affecting survival of patients, and BSJP exerted a more significant effect on patients at BCLC-C stage (RR = 0.513; P = 0.002).
Conclusion: BSJP therapy and locoregional therapy both contributed to prolonged survival for moderate and advanced HCC patients.
Keywords: Bushen Jianpi formula; Carcinoma, hepatocellular; Retrospective studie; Survival analysi.