The Current State of Mohs Surgery for the Treatment of Melanoma: A Nationwide Cross-Sectional Survey of Mohs Surgeons

Dermatol Surg. 2020 Oct;46(10):1267-1271. doi: 10.1097/DSS.0000000000002645.

Abstract

Background: The increased use of Mohs micrographic surgery (MMS) to treat melanoma has been accompanied by wide variations in practice patterns and a lack of best practice guidelines.

Objective: The present study was a nationwide cross-sectional survey of Mohs surgeons to elucidate commonalities and variations in their use of MMS to treat melanoma.

Materials and methods: A cross-sectional analysis was performed using survey responses of Mohs surgeons with membership in the American College of Mohs Surgery.

Results: A total of 210/513 (40.9%) participants used MMS to treat melanoma of any subtype and 123/210 (58.6%) participants within this group treated invasive T1 melanoma (AJCC Eighth Edition) with MMS. A total of 172/210 (81.9%) participants debulked melanoma in situ (MIS). Average margin size of the first Mohs stage for MIS was 4.96 ± 1.74 mm. A total of 149/210 (71.0%) participants used immunohistochemical stains, with 145/149 (97.3%) using melanoma antigen recognized by T-cells 1 (MART-1) in 96.5% of melanoma cases treated with MMS.

Conclusion: Over half of surveyed Mohs surgeons treating melanoma with MMS are treating early invasive melanoma with MMS. Most Mohs surgeons treating melanoma with MMS debulk MIS and virtually all use MART-1 when excising invasive melanoma with MMS.

MeSH terms

  • Adult
  • Cross-Sectional Studies
  • Cytoreduction Surgical Procedures / methods
  • Cytoreduction Surgical Procedures / standards
  • Cytoreduction Surgical Procedures / statistics & numerical data*
  • Female
  • Humans
  • Immunohistochemistry
  • MART-1 Antigen / analysis
  • Male
  • Margins of Excision
  • Melanoma / diagnosis
  • Melanoma / pathology
  • Melanoma / surgery*
  • Middle Aged
  • Mohs Surgery / methods
  • Mohs Surgery / standards
  • Mohs Surgery / statistics & numerical data*
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Practice Guidelines as Topic
  • Practice Patterns, Physicians' / standards
  • Practice Patterns, Physicians' / statistics & numerical data*
  • Skin / pathology
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / pathology
  • Skin Neoplasms / surgery*
  • Surgeons / standards
  • Surgeons / statistics & numerical data
  • Treatment Outcome

Substances

  • MART-1 Antigen
  • MLANA protein, human