Prospects and Clinical Perspectives of Total-Body PET Imaging Using Plastic Scintillators

Paweł Moskal; Ewa Ł Stępień

doi:10.1016/j.cpet.2020.06.009

Prospects and Clinical Perspectives of Total-Body PET Imaging Using Plastic Scintillators

PET Clin. 2020 Oct;15(4):439-452. doi: 10.1016/j.cpet.2020.06.009. Epub 2020 Jul 29.

Authors

Paweł Moskal¹, Ewa Ł Stępień²

Affiliations

¹ Marian Smoluchowski Institute of Physics, Jagiellonian University, ul. S. Lojasiewicza 11, Kraków 30-348, Poland. Electronic address: p.moskal@uj.edu.pl.
² Marian Smoluchowski Institute of Physics, Jagiellonian University, ul. S. Lojasiewicza 11, Kraków 30-348, Poland. Electronic address: e.stepien@uj.edu.pl.

PMID: 32739047
DOI: 10.1016/j.cpet.2020.06.009

Abstract

Total-body PET opens a new diagnostic paradigm with prospects for personalized disease treatment, yet the high cost of the current crystal-based PET technology limits dissemination of total-body PET in hospitals and even in research clinics. The J-PET tomography system is based on axially arranged low-cost plastic scintillator strips. It constitutes a realistic cost-effective solution of a total-body PET for broad clinical applications. High sensitivity of total-body J-PET and triggerless data acquisition enable multiphoton imaging, opening possibilities for multitracer and positronium imaging, thus promising quantitative enhancement of specificity in cancer and inflammatory disease assessment.

Keywords: (44)Sc-PSMA; (82)Rb-chloride; J-PET; Multitracer imaging; PET imaging; Plastic scintillators; Positronium imaging; Total-body PET imaging.

Publication types

Review

MeSH terms

Humans
Plastics
Positron-Emission Tomography / instrumentation*
Positron-Emission Tomography / methods*
Whole Body Imaging / methods*

Substances

Plastics