The association of genetic variants IL2RA rs2104286, IFI30 rs11554159 and IKZF3 rs12946510 with multiple sclerosis onset and severity in patients from Serbia

J Neuroimmunol. 2020 Oct 15:347:577346. doi: 10.1016/j.jneuroim.2020.577346. Epub 2020 Jul 25.

Abstract

An algorithm Probabilistic Identification of Causal SNPs, identified 434 causal variants for multiple sclerosis (MS) including IL2RA rs2104286, IFI30 rs11554159 and IKZF3 rs12946510. Analysis of individual and combined effects of these variants in the Serbian population identified that Il2RA rs2104286 G allele carriers had a lower risk for developing MS (gender adjusted OR = 0.63, p = .003). With regard to the IFI30 rs11554159 recessive genetic model, among HLA-DRB1*15:01 positive patients, the AA homozygote had a significantly higher MSSS compared to the G allele carriers (p = .003). This study confirms role of IL2RA rs2104286 in MS and suggest the role of IFI30 rs11554159 in disease severity, which needs validation.

Keywords: Disease severity; Genetic variants; IFI30; IKZF3; IL2RA; Multiple sclerosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Genetic Association Studies / methods
  • Genetic Variation / genetics*
  • Humans
  • Ikaros Transcription Factor / genetics*
  • Interleukin-2 Receptor alpha Subunit / genetics*
  • Male
  • Middle Aged
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / genetics*
  • Oxidoreductases Acting on Sulfur Group Donors / genetics*
  • Serbia / epidemiology
  • Severity of Illness Index*

Substances

  • IKZF3 protein, human
  • IL2RA protein, human
  • Interleukin-2 Receptor alpha Subunit
  • Ikaros Transcription Factor
  • IFI30 protein, human
  • Oxidoreductases Acting on Sulfur Group Donors