miR-137: A Novel Therapeutic Target for Human Glioma

Yajun Wang; Riling Chen; Xia Zhou; Runmin Guo; Jingwen Yin; You Li; Guoda Ma

doi:10.1016/j.omtn.2020.06.028

miR-137: A Novel Therapeutic Target for Human Glioma

Mol Ther Nucleic Acids. 2020 Sep 4:21:614-622. doi: 10.1016/j.omtn.2020.06.028. Epub 2020 Jun 30.

Authors

Yajun Wang¹, Riling Chen², Xia Zhou³, Runmin Guo², Jingwen Yin⁴, You Li⁵, Guoda Ma⁶

Affiliations

¹ Maternal and Children's Health Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan 528300, China; Clinical Research Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China; Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.
² Maternal and Children's Health Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan 528300, China.
³ Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
⁴ Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
⁵ Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China. Electronic address: dreamly2001@126.com.
⁶ Maternal and Children's Health Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan 528300, China. Electronic address: sihan1107@126.com.

Abstract

MicroRNA (miR)-137 is highly expressed in the brain and plays a crucial role in the development and prognosis of glioma. In this review, we aim to summarize the latest findings regarding miR-137 in glioma cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer treatment. In addition, we focus on the identified miR-137 targets and pathways in the occurrence and development of glioma. Finally, future implications for the diagnostic and therapeutic potential of miR-137 in glioma were discussed.

Keywords: diagnosis; glioma; miR-137; target genes; treatment.

Publication types

Review