Light-triggered redox activity of GdYVO4:Eu3+ nanoparticles

S L Yefimova; P O Maksimchuk; K O Hubenko; V V Omielaieva; N S Kavok; V K Klochkov; Yu V Malyukin; V P Semynozhenko

doi:10.1016/j.saa.2020.118741

Light-triggered redox activity of GdYVO₄:Eu³⁺ nanoparticles

Spectrochim Acta A Mol Biomol Spectrosc. 2020 Dec 5:242:118741. doi: 10.1016/j.saa.2020.118741. Epub 2020 Jul 21.

Authors

S L Yefimova¹, P O Maksimchuk², K O Hubenko², V V Omielaieva², N S Kavok², V K Klochkov², Yu V Malyukin², V P Semynozhenko³

Affiliations

¹ Institute for Scintillation Materials National Academy of Sciences of Ukraine, 60 Nauky Ave., 61072 Kharkiv, Ukraine. Electronic address: ephimova@isma.kharkov.ua.
² Institute for Scintillation Materials National Academy of Sciences of Ukraine, 60 Nauky Ave., 61072 Kharkiv, Ukraine.
³ SSI "Institute for Single Crystal" National Academy of Sciences of Ukraine, 60 Nauky Ave., 61072 Kharkiv, Ukraine.

PMID: 32736222
DOI: 10.1016/j.saa.2020.118741

Abstract

Light-triggered redox activity of small (d = 2 nm) GdYVO₄:Eu³⁺ nanoparticles (NPs) in aqueous solutions and lipid suspensions is reported. It has been revealed that depending on pre-treatment conditions (exposure to UV light or storage in the dark) the same NPs exhibit pro- or anti-oxidant properties. Pro-/anti-oxidant activity in aqueous solutions was evaluated by UV-vis spectroscopy using probe molecules for hydroxyl radicals (·OH) and superoxide anions (O₂^•-). Lipid oxidation under the effect of NPs has been also analyzed. Multi-functional GdYVO₄:Eu³⁺ NPs are assumed to be a new theranostic agent in cancer therapy, which exhibit fluorescent properties, triggered redox activity and drug-carrier ability.

Keywords: Hydroxyl radical; Light-triggered redox activity; Nanoparticles; Radical scavenging; Superoxide anion; UV irradiation.