STAT3 Contributes to Radioresistance in Cancer

Xuehai Wang; Xin Zhang; Chen Qiu; Ning Yang

doi:10.3389/fonc.2020.01120

STAT3 Contributes to Radioresistance in Cancer

Front Oncol. 2020 Jul 7:10:1120. doi: 10.3389/fonc.2020.01120. eCollection 2020.

Authors

Xuehai Wang¹, Xin Zhang^{2

3}, Chen Qiu⁴, Ning Yang^{2

3}

Affiliations

¹ Department of Otolaryngology, Weihai Municipal Hospital, Shandong University, Weihai, China.
² Department of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.
³ Shandong Key Laboratory of Brain Function Remodeling, Jinan, China.
⁴ Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, China.

Abstract

Radiotherapy has been used in the clinic for more than one century and it is recognized as one of the main methods in the treatment of malignant tumors. Signal Transducers and Activators of Transcription 3 (STAT3) is reported to be upregulated in many tumor types, and it is believed to be involved in the tumorigenesis, development and malignant behaviors of tumors. Previous studies also found that STAT3 contributes to chemo-resistance of various tumor types. Recently, many studies reported that STAT3 is involved in the response of tumor cells to radiotherapy. But until now, the role of the STAT3 in radioresistance has not been systematically demonstrated. In this study, we will review the radioresistance induced by STAT3 and relative solutions will be discussed.

Keywords: STAT3; aggressive behaviors; apoptosis; cancer cell stemness; reactive oxygen species.

Publication types

Review