Biogenesis of the peptide-derived redox cofactor pyrroloquinoline quinone

Wen Zhu; Judith P Klinman

doi:10.1016/j.cbpa.2020.05.001

Biogenesis of the peptide-derived redox cofactor pyrroloquinoline quinone

Curr Opin Chem Biol. 2020 Dec:59:93-103. doi: 10.1016/j.cbpa.2020.05.001. Epub 2020 Jul 27.

Authors

Wen Zhu¹, Judith P Klinman²

Affiliations

¹ California Institute for Quantitative Biosciences and Department of Chemistry, University of California, Berkeley, CA, 94720-3220, USA.
² California Institute for Quantitative Biosciences and Department of Chemistry, University of California, Berkeley, CA, 94720-3220, USA; Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720-3220, USA. Electronic address: klinman@berkeley.edu.

Abstract

Pyrroloquinoline quinone (PQQ) is a peptide-derived redox cofactor produced by prokaryotes that also plays beneficial roles in organisms from other kingdoms. We review recent developments on the pathway of PQQ biogenesis, focusing on the mechanisms of PqqE, PqqF/G, and PqqB. These advances may shed light on other, uncharacterized biosynthetic pathways.

Keywords: Biosynthesis; Cofactor; Cofactorless oxidase; Nonheme iron-dependent hydroxylase; PQQ; Peptidase; Peptide; PqqA; PqqB; PqqC; PqqD; PqqE; PqqF; PqqG; Radical SAM enzyme.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Bacteria / metabolism*
Bacterial Proteins / metabolism
Biosynthetic Pathways*
Models, Molecular
Oxidation-Reduction
PQQ Cofactor / metabolism*

Substances

Bacterial Proteins
PQQ Cofactor

Grants and funding

R35 GM118117/GM/NIGMS NIH HHS/United States