Pediatric ovarian Sertoli-Leydig cell tumors with heterologous rhabdomyosarcoma elements: Clinical case series and review of the literature

Jane Koo; Timothy P Garrington; Karol Kerr; Amy L Treece; Carrye R Cost

doi:10.1002/pbc.28621

Pediatric ovarian Sertoli-Leydig cell tumors with heterologous rhabdomyosarcoma elements: Clinical case series and review of the literature

Pediatr Blood Cancer. 2020 Oct;67(10):e28621. doi: 10.1002/pbc.28621. Epub 2020 Jul 30.

Authors

Jane Koo¹, Timothy P Garrington¹, Karol Kerr¹, Amy L Treece², Carrye R Cost¹

Affiliations

¹ Department of Pediatric Hematology/Oncology/Bone Marrow Transplant, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, Colorado.
² Department of Pathology and Laboratory Medicine, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, Colorado.

PMID: 32729194
DOI: 10.1002/pbc.28621

Abstract

Sertoli-Leydig cell tumors (SLCTs) are rare ovarian neoplasms in pediatric patients. More exceedingly rare are SLCTs that also contain heterologous rhabdomyosarcoma (RMS) elements. For these patients, there is no standardized treatment. We report four cases of pediatric SLCT with heterologous RMS elements that were successfully treated with surgical resection and adjuvant chemotherapy. All four patients are alive and remain in remission.

Keywords: Sertoli-Leydig cell tumor; heterologous elements; rhabdomyosarcoma.

Publication types

Case Reports
Review

MeSH terms

Adolescent
Combined Modality Therapy
Female
Follow-Up Studies
Humans
Ovarian Neoplasms / pathology*
Ovarian Neoplasms / therapy
Prognosis
Retrospective Studies
Rhabdomyosarcoma, Embryonal / pathology*
Rhabdomyosarcoma, Embryonal / therapy
Sertoli-Leydig Cell Tumor / pathology*
Sertoli-Leydig Cell Tumor / therapy