Introduction: Platelet diseases and dysfunction are taught early in medical school to all future physicians. Understanding of the coagulation cascade and hemostatic mechanisms has allowed for targeted pharmacological therapies that have been significantly impactful in clinical practice. Platelets are an early participant in hemostasis physiologically and under pathophysiological states.
Methods: A review of literature involving platelet disfunction.
Results: Various presentations of platelet diseases and dysfunction challenge clinicians and require a firm understanding of normal platelet function, drugs that mediate or modulate platelet effectiveness, and nonpharmacologic etiologies of platelet diseases and dysfunction with corresponding best practice treatment approaches.
Conclusion: This review summarizes normal and abnormal states associated with platelets and treatment strategies.
Keywords: Hemostasis; Platelet disfunction; Systemic lupus erythematosus; Thrombotic thrombocytopenic purpura.