Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report

J Cardiothorac Surg. 2020 Jul 29;15(1):196. doi: 10.1186/s13019-020-01178-z.

Abstract

Background: Routine clinical and pathological examinations usually cannot fully conclusively determine the relationship between different lesions of lung cancer. Detailed genetic analysis of tumor samples may supply important additional information and identify second primary lung cancers.

Case presentation: In the present study, we report a case of synchronous multiple primary lung cancer (MPLC) composed of two distinct pathological subtypes with epidermal growth factor receptor (EGFR) gene mutations L858R of the acinar adenocarcinoma subtype and EML4-ALK rearrangement of the squamous cell carcinoma.

Conclusion: The present report highlights the clinical importance of molecular cancer biomarkers detection to guide management decisions in MPLC cases.

Keywords: ALK; Case report; EGFR; Multiple primary lung cancer.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma of Lung / diagnostic imaging
  • Adenocarcinoma of Lung / genetics*
  • Adenocarcinoma of Lung / pathology
  • Aged
  • ErbB Receptors / genetics
  • Humans
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • Male
  • Mutation
  • Neoplasms, Multiple Primary / diagnostic imaging
  • Neoplasms, Multiple Primary / genetics*
  • Neoplasms, Multiple Primary / pathology
  • Oncogene Proteins, Fusion / genetics*
  • Tomography, X-Ray Computed

Substances

  • EML4-ALK fusion protein, human
  • Oncogene Proteins, Fusion
  • EGFR protein, human
  • ErbB Receptors