Genetic Susceptibility of the Host in Virus-Induced Diabetes

Keiichiro Mine; Yasunobu Yoshikai; Hirokazu Takahashi; Hitoe Mori; Keizo Anzai; Seiho Nagafuchi

doi:10.3390/microorganisms8081133

Genetic Susceptibility of the Host in Virus-Induced Diabetes

Microorganisms. 2020 Jul 27;8(8):1133. doi: 10.3390/microorganisms8081133.

Authors

Keiichiro Mine^{1

2}, Yasunobu Yoshikai², Hirokazu Takahashi^{1

3}, Hitoe Mori¹, Keizo Anzai¹, Seiho Nagafuchi¹

Affiliations

¹ Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan.
² Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
³ Liver Center, Saga University Hospital, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan.

Abstract

Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of target genes in VID. In this review, we describe the genetic susceptibility of the host based on studies in humans and VID animal models. Understanding the host genetic factors should contribute not only to revealing the mechanisms of VID development, but also in taking measures to prevent VID.

Keywords: diabetes; susceptibility genes; virus.

Publication types

Review

Abstract

Publication types

Grants and funding