Pulmonary function in patients surviving to COVID-19 pneumonia

Infection. 2021 Feb;49(1):153-157. doi: 10.1007/s15010-020-01474-9. Epub 2020 Jul 28.

Abstract

Purpose: The aim of our study was to assess respiratory function at the time of clinical recovery and 6 weeks after discharge in patients surviving to COVID-19 pneumonia.

Methods: Our case series consisted of 13 patients with COVID-19 pneumonia.

Results: At the time of clinical recovery, FEV1 (2.07 ± 0.72 L) and FVC (2.25 ± 0.86 L) were lower compared to lower limit of normality (LLN) values (2.56 ± 0.53 L, p = 0.004, and 3.31 ± 0.65 L, p < 0.001, respectively), while FEV1/FVC (0.94 ± 0.07) was higher compared to upper limit of normality (ULN) values (0.89 ± 0.01, p = 0.029). After 6 weeks pulmonary function improved but FVC was still lower than ULN (2.87 ± 0.81, p = 0.014).

Conclusion: These findings suggest that COVID-19 pneumonia may result in clinically relevant alterations in pulmonary function tests, with a mainly restrictive pattern.

Keywords: COVID-19; Pneumonia; Spirometry.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • COVID-19 / diagnosis
  • COVID-19 / pathology
  • COVID-19 / physiopathology*
  • COVID-19 / virology
  • Cough / diagnosis
  • Cough / pathology
  • Cough / physiopathology*
  • Cough / virology
  • Dyspnea / diagnosis
  • Dyspnea / pathology
  • Dyspnea / physiopathology*
  • Dyspnea / virology
  • Female
  • Fever / diagnosis
  • Fever / pathology
  • Fever / physiopathology*
  • Fever / virology
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung / physiopathology*
  • Lung / virology
  • Male
  • Middle Aged
  • Respiratory Function Tests
  • SARS-CoV-2 / pathogenicity*
  • Spirometry
  • Tomography, X-Ray Computed