Effect of dexmedetomidine on brain function and hemodynamics in patients undergoing lung cancer resection

Yunfeng Li; Chunyu Wang; Mingzhuang Bi; Jie Gao; Xue Zhang; Haitao Tian

doi:10.3892/ol.2020.11675

Effect of dexmedetomidine on brain function and hemodynamics in patients undergoing lung cancer resection

Oncol Lett. 2020 Aug;20(2):1077-1082. doi: 10.3892/ol.2020.11675. Epub 2020 May 28.

Authors

Yunfeng Li¹, Chunyu Wang², Mingzhuang Bi³, Jie Gao⁴, Xue Zhang⁴, Haitao Tian^{5

6}

Affiliations

¹ Department of Pharmacy, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.
² Department of Anesthesiology, Qingdao Eighth People's Hospital, Qingdao, Shandong 266100, P.R. China.
³ Department of Anesthesiology, Qingdao Women and Children's Hospital, Qingdao, Shandong 266034, P.R. China.
⁴ Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.
⁵ Department of Anesthesiology, Jining No. 1 People's Hospital, Jining, Shandong 272000, P.R. China.
⁶ Jining Medical University, Jining, Shandong 272000, P.R. China.

Abstract

Effect of dexmedetomidine on the brain function and hemodynamics in patients undergoing lung cancer resection were explored. Eighty-seven patients with lung cancer undergoing lung cancer resection in Weifang People's Hospital from January 2014 to June 2018 were enrolled in this study. Patients conventionally anesthetized by propofol, midazolam, sufentanil, or cisatracurium besilate (41 cases) were assigned to the control group and those anesthetized by conventional anesthetic and dexmedetomidine (46 cases) were assigned to the research group. The hemodynamic parameters, neuron-specific enolase (NSE), and astrocyte S-100p protein (S-100β) were compared between the two groups before induction (T0), 5 min after induction (T1), at the end of surgery (T2), time of extubation (T3), and 5 min after extubation (T4). The cognitive function of patients was graded by the mini-mental state examination (MMSE) after patients recovered from anesthesia. In both the control group and the research group, the levels of mean arterial pressure (MAP), heart rate (HR), and central venous pressure (CVP). were statistically higher at T2 and T3 than those at T0 (all P<0.05). The levels of MAP, HR, and CVP were statistically lower in the research group than those in the control group at T2 and T3 (P<0.05). The levels of serum NSE and S100β protein in the research group and the control group increased at T2, T3, and T4, the control group was higher than the research group at each time point, and the difference was statistically significant (P<0.05). Comparison of the MMSE score and the total case number of adverse reactions between the two groups showed no statistical difference (both P>0.05). The MMSE score was positively correlated with the serum levels of NSE and S100β in the two groups (r-values were 0.661 and 0.585, P<0.05). Dexmedetomidine can effectively protect patients' perioperative brain function with small impacts on perioperative hemodynamics, so it is worthy of clinical application.

Keywords: brain function; cognitive function; dexmedetomidine; hemo-dynamics; lung cancer.