Feasibility of laparoscopic ovarian tissue cryopreservation after open abdominopelvic tumor surgery

Am J Surg. 2020 Nov;220(5):1249-1252. doi: 10.1016/j.amjsurg.2020.06.040. Epub 2020 Jul 9.

Abstract

Background: Laparoscopic oophorectomy with tissue cryopreservation (OTC) for fertility preservation is usually performed prior to therapy. When fertility preservation is considered after prior open abdominopelvic tumor surgery there may be a perceived barrier to laparoscopic OTC. This study evaluates the feasibility of OTC with a laparoscopic approach after open surgery.

Methods: This is a single institution retrospective study from 2011 to 2019.

Results: Planned laparoscopic OTC was performed after open surgery in 17 of 113 patients. Median age was 4.2 years. The most common diagnoses were Wilms Tumor (35%) and neuroblastoma (35%). The most common procedures were nephrectomy (41%) and exploratory laparotomy with biopsy (35%). The median amount of time between open surgery and OTC was 29 days. Sixteen (94%) had a laparoscopic OTC. Regardless of operative technique, patients resumed therapy a median of 3 days after OTC.

Conclusions: Prior abdominopelvic surgery should not be a barrier to OTC. Laparoscopic OTC is feasible after a variety of open oncologic operations, regardless of time-interval between the procedures and without incurring a significant delay in resuming oncologic therapy.

MeSH terms

  • Abdominal Neoplasms / surgery*
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Cryopreservation / methods*
  • Feasibility Studies
  • Female
  • Fertility Preservation / methods*
  • Humans
  • Infant
  • Infant, Newborn
  • Laparoscopy*
  • Ovariectomy*
  • Ovary / surgery*
  • Pelvic Neoplasms / surgery*
  • Retrospective Studies
  • Young Adult