Briarenols Q-T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908)

Yi-Lin Zhang; Chih-Chao Chiang; Yi-Ting Lee; Zhi-Hong Wen; Yang-Chang Wu; Yu-Jen Wu; Tsong-Long Hwang; Tung-Ying Wu; Chia-Yuan Chang; Ping-Jyun Sung

doi:10.3390/md18080383

Briarenols Q-T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908)

Mar Drugs. 2020 Jul 24;18(8):383. doi: 10.3390/md18080383.

Authors

Yi-Lin Zhang^{1

2}, Chih-Chao Chiang³, Yi-Ting Lee⁴, Zhi-Hong Wen^{4

5}, Yang-Chang Wu^{6

7}, Yu-Jen Wu⁸, Tsong-Long Hwang^{9

10

11

12

13}, Tung-Ying Wu^{14

15}, Chia-Yuan Chang¹⁶, Ping-Jyun Sung^{1

2

4

7

17}

Affiliations

¹ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944401, Taiwan.
² National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan.
³ Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.
⁴ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
⁵ Institute of BioPharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
⁶ Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404333, Taiwan.
⁷ Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404394, Taiwan.
⁸ Department of Nursing, Meiho University, Pingtung 912009, Taiwan.
⁹ Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan.
¹⁰ Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.
¹¹ Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333323, Taiwan.
¹² Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan.
¹³ Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan.
¹⁴ Department of Biological Science & Technology, Meiho University, Pingtung 912009, Taiwan.
¹⁵ Department of Food Science and Nutrition, Meiho University, Pingtung 912009, Taiwan.
¹⁶ Department of Neurosurgery, Antai Medical Care Corporation Antai Tian-Sheng Memorial Hospital, Pingtung 928004, Taiwan.
¹⁷ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.

Abstract

Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q-T (1-4). The structures of new metabolites 1-4 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS).

Keywords: Briareum stechei; COX-2; briarane; briarenol; iNOS.

Publication types

Comparative Study

MeSH terms

Animals
Anthozoa / metabolism*
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology*
Cyclooxygenase 2 / metabolism
Diterpenes / chemistry
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Lipopolysaccharides / pharmacology
Macrophages / drug effects*
Macrophages / enzymology
Mice
Molecular Structure
Nitric Oxide / metabolism
Nitric Oxide Synthase Type II / metabolism
RAW 264.7 Cells
Structure-Activity Relationship

Substances

Anti-Inflammatory Agents
Diterpenes
Lipopolysaccharides
Nitric Oxide
Nitric Oxide Synthase Type II
Nos2 protein, mouse
Ptgs2 protein, mouse
Cyclooxygenase 2