ESMO management and treatment adapted recommendations in the COVID-19 era: gynaecological malignancies

ESMO Open. 2020 Jul;5(Suppl 3):e000827. doi: 10.1136/esmoopen-2020-000827.

Abstract

The rapid spread of severe acute respiratory syndrome coronavirus 2 infection and its related disease (COVID-19) has required an immediate and coordinate healthcare response to face the worldwide emergency and define strategies to maintain the continuum of care for the non-COVID-19 diseases while protecting patients and healthcare providers. The dimension of the COVID-19 pandemic poses an unprecedented risk especially for the more vulnerable populations. To manage patients with cancer adequately, maintaining the highest quality of care, a definition of value-based priorities is necessary to define which interventions can be safely postponed without affecting patients' outcome. The European Society for Medical Oncology (ESMO) has endorsed a tiered approach across three different levels of priority (high, medium, low) incorporating information on the value-based prioritisation and clinical cogency of the interventions that can be applied for different disease sites. Patients with gynaecological cancer are at particular risk of COVID-19 complications because of their age and prevalence of comorbidities. The definition of priority level should be based on tumour stage and histology, cancer-related symptoms or complications, aim (curative vs palliative) and magnitude of benefit of the oncological intervention, patients' general condition and preferences. The decision-making process always needs to consider the disease-specific national and international guidelines and the local healthcare system and social resources, and a changing situation in relation to COVID-19 infection. These recommendations aim to provide guidance for the definition of deferrable and undeferrable interventions during the COVID-19 pandemic for ovarian, endometrial and cervical cancers within the context of the ESMO Clinical Practice Guidelines.

Keywords: COVID-19; cervical cancer; endometrial cancer; ovarian cancer; value-based priorities.

Publication types

  • Review

MeSH terms

  • Betacoronavirus / physiology
  • COVID-19
  • Comorbidity
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / therapy*
  • Coronavirus Infections / virology
  • Delivery of Health Care / statistics & numerical data
  • Delivery of Health Care / trends
  • Endometrial Neoplasms / diagnosis
  • Endometrial Neoplasms / epidemiology
  • Endometrial Neoplasms / therapy
  • Europe / epidemiology
  • Female
  • Genital Neoplasms, Female / diagnosis
  • Genital Neoplasms, Female / epidemiology
  • Genital Neoplasms, Female / therapy*
  • Humans
  • Medical Oncology / methods*
  • Medical Oncology / organization & administration
  • Ovarian Neoplasms / diagnosis
  • Ovarian Neoplasms / epidemiology
  • Ovarian Neoplasms / therapy
  • Pandemics
  • Pneumonia, Viral / epidemiology
  • Pneumonia, Viral / therapy*
  • Pneumonia, Viral / virology
  • Practice Guidelines as Topic*
  • SARS-CoV-2
  • Societies, Medical
  • Uterine Cervical Neoplasms / diagnosis
  • Uterine Cervical Neoplasms / epidemiology
  • Uterine Cervical Neoplasms / therapy