The Background K+ Channel TRESK in Sensory Physiology and Pain

Int J Mol Sci. 2020 Jul 23;21(15):5206. doi: 10.3390/ijms21155206.

Abstract

TRESK belongs to the K2P family of potassium channels, also known as background or leak potassium channels due to their biophysical properties and their role regulating membrane potential of cells. Several studies to date have highlighted the role of TRESK in regulating the excitability of specific subtypes of sensory neurons. These findings suggest TRESK could be involved in pain sensitivity. Here, we review the different evidence available that involves the channel in pain and sensory perception, from studies knocking out the channel or overexpressing it to identified mutations that link the channel to migraine pain. In addition, the therapeutic possibilities are discussed, as targeting the channel seems an interesting therapeutic approach to reduce nociceptor activation and to decrease pain.

Keywords: hyperexcitability; migraine; pain; potassium channel; sensory neuron; somatosensation.

Publication types

  • Review

MeSH terms

  • Humans
  • Membrane Potentials / genetics*
  • Migraine Disorders / genetics
  • Migraine Disorders / metabolism
  • Migraine Disorders / pathology
  • Migraine Disorders / therapy
  • Mutation*
  • Nociception*
  • Pain Management*
  • Pain* / genetics
  • Pain* / metabolism
  • Pain* / pathology
  • Potassium Channels* / genetics
  • Potassium Channels* / metabolism
  • Sensory Receptor Cells* / metabolism
  • Sensory Receptor Cells* / pathology

Substances

  • KCNK18 protein, human
  • Potassium Channels