New thiophene hydrazide dual-functional chemosensor: Colorimetric sensor for Cu2+ & fluorescent sensor for Al3

Zhenyu Zuo; Yuping Tang; Fuhou Lei; Ruyi Jin; Pengcheng Yin; Yang Li; Qingfen Niu

doi:10.1016/j.saa.2020.118712

New thiophene hydrazide dual-functional chemosensor: Colorimetric sensor for Cu²⁺ & fluorescent sensor for Al³

Spectrochim Acta A Mol Biomol Spectrosc. 2020 Dec 5:242:118712. doi: 10.1016/j.saa.2020.118712. Epub 2020 Jul 20.

Authors

Zhenyu Zuo¹, Yuping Tang², Fuhou Lei³, Ruyi Jin², Pengcheng Yin⁴, Yang Li⁴, Qingfen Niu⁵

Affiliations

¹ Department of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, People's Republic of China; Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning 530006, People's Republic of China. Electronic address: zuozhenyu666@sina.cn.
² Department of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, People's Republic of China.
³ Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning 530006, People's Republic of China.
⁴ Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, People's Republic of China.
⁵ Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, People's Republic of China. Electronic address: qf_niu1216@qlu.edu.cn.

PMID: 32717524
DOI: 10.1016/j.saa.2020.118712

Abstract

A new thiophene hydrazide derivative TSB was synthesized and utilized as naked-eye colorimetric sensor for Cu²⁺ by the color changed from colorless to yellow as well as green fluorescent turn on sensor for Al³⁺ in DMSO/H₂O (1/1, V/V) solution. The dual-functional chemosensor TSB for Cu²⁺/Al³⁺ sensing displayed excellent properties of special selectivity, superior sensitivity, outstanding anti-interference performance, instantaneous response, wide pH working range and good reversibility. The detection limits of TSB for Cu²⁺/Al³⁺ were determined as low as 46.5 nM and 32.7 nM, respectively. The 1:1 binding mode of TSB with Cu²⁺/Al³⁺ was proved by spectrometric titrations, Job's plots, FTIR, ¹H NMR and HRMS analysis. Moreover, chemosensor TSB was successfully utilized for detection of Cu²⁺ and Al³⁺ in real environmental water and food samples with high reliability, demonstrating its practical applicability.

Keywords: Al(3+); Colorimetric sensor; Cu(2+); Fluorimetric sensor; Thiophene hydrazide derivative.